Endocrine Abstracts

With the aim of identifying genes involved in the development of pituitary tumors, we used the mRNA differential display technique comparing tumor and normal pituitary cells. Two genes have been identified to be involved in pathogenesis process: in prolactinomas obtained from Dopamine D2R knockout female mice, we have found differential expression of the cytokine BPMP-4 and in clones of the tumoral lactosomatroph cell line GH3 cell line overexpressing the cytokine IL6 signal t...